USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P55212 USC-OGP 2-DE database:  P55212 P55212 General information about the entry View entry in simple text format Entry name CASP6_HUMAN Primary accession number P55212 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Caspase-6; Short=CASP-6; EC=3.4.22.59; AltName: Full=Apoptotic protease Mch-2; Contains: RecName: Full=Caspase-6 subunit p18; Contains: RecName: Full=Caspase-6 subunit p11; Flags: Precursor;. Gene name Name=CASP6 Synonyms=MCH2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0985: pI=6.04; Mw=28989 Cross-references UniProtKB/Swiss-Prot P55212; CASP6_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CASP6_HUMAN Primary accession number P55212 Secondary accession number(s) Q9BQE7 Sequence was last modified on  November 28, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 183) Name and origin of the protein Description RecName: Full=Caspase-6; Short=CASP-6; EC=3.4.22.59; AltName: Full=Apoptotic protease Mch-2; Contains: RecName: Full=Caspase-6 subunit p18; Contains: RecName: Full=Caspase-6 subunit p11; Flags: Precursor; Gene name Name=CASP6 Synonyms=MCH2 Encoded on Name=CASP6; Synonyms=MCH2 Keywords 3D-structure; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Protease; Reference proteome; Thiol protease; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U20536; AAC50168.1; -; mRNA EMBL U20537; AAC50169.1; -; mRNA EMBL AY254046; AAO63494.1; -; Genomic_DNA EMBL BC000305; AAH00305.1; -; mRNA EMBL BC004460; AAH04460.1; -; mRNA CCDS CCDS3684.1; -. [P55212-1]; . CCDS CCDS3685.1; -. [P55212-2]; . RefSeq NP_001217.2; NM_001226.3. [P55212-1]; . RefSeq NP_116787.1; NM_032992.2. [P55212-2]; . UniGene Hs.654616; -; . PDB 1MI9; Model; -; A=34-175 B=198-290 PDB; 2WDP; X-ray; 1.95 A A/B/C/D=1-293 PDB; 3K7E; X-ray; 3.00 A A/B/C/D=24-293 PDB; 3NKF; X-ray; 2.90 A A/B/C/D=24-293 PDB; 3NR2; X-ray; 2.90 A A/B=24-293 PDB; 3OD5; X-ray; 1.60 A A/B=24-293 PDB; 3P45; X-ray; 2.53 A A/C/E/G/I/K/M/O=1-179 B/D/F/H/J/L/N/P=193-293; PDB; 3P4U; X-ray 1.90 A A/C=23-179; B/D=193-293; PDB; 3QNW X-ray 2.65 A; A/C/E/G=24-179; B/D/F/H=194-293; PDB 3S70 X-ray; 1.62 A; A/C=24-293; PDB 3S8E X-ray; 2.88 A; A/B/C/D/E/F/G/H=24-293; PDB 3V6L X-ray; 2.20 A; A/B=21-293; PDB 3V6M X-ray; 2.69 A; A/B/C/D/F/G/I/J=24-293; PDB 4EJF X-ray; 2.65 A; A/B/C/D=24-293; PDB 4FXO X-ray; 2.85 A; A/B/C/D=1-293; PDB 4HVA X-ray; 2.07 A; A/B=24-293; PDB 4IYR X-ray; 2.70 A; A/B=1-293; PDB 4N5D X-ray; 2.06 A; A/B=24-293; PDB 4N6G X-ray; 2.14 A; A/B=24-293; PDB 4N7J X-ray; 1.67 A; A/B=24-293; PDB 4N7M X-ray; 2.12 A; A/B=24-293; PDB 4NBK X-ray; 1.94 A; A/B=24-293; PDB 4NBL X-ray; 1.76 A; A/B=24-293; PDB 4NBN X-ray; 1.75 A; A/B=24-293; PDBsum 1MI9 -; . PDBsum 2WDP; -; . PDBsum 3K7E; -; . PDBsum 3NKF; -; . PDBsum 3NR2; -; . PDBsum 3OD5; -; . PDBsum 3P45; -; . PDBsum 3P4U; -; . PDBsum 3QNW; -; . PDBsum 3S70; -; . PDBsum 3S8E; -; . PDBsum 3V6L; -; . PDBsum 3V6M; -; . PDBsum 4EJF; -; . PDBsum 4FXO; -; . PDBsum 4HVA; -; . PDBsum 4IYR; -; . PDBsum 4N5D; -; . PDBsum 4N6G; -; . PDBsum 4N7J; -; . PDBsum 4N7M; -; . PDBsum 4NBK; -; . PDBsum 4NBL; -; . PDBsum 4NBN; -; . ProteinModelPortal P55212; -; . SMR P55212; -; . BioGrid 107289; 19; . DIP DIP-44649N; -; . IntAct P55212; 15; . MINT MINT-1374245; -; . STRING 9606.ENSP00000265164; -; . BindingDB P55212; -; . ChEMBL CHEMBL3308; -; . GuidetoPHARMACOLOGY 1622; -; . MEROPS C14.005; -; . iPTMnet P55212; -; . PhosphoSitePlus P55212; -; . BioMuta CASP6; -; . DMDM 26006981; -; . OGP P55212; -; . EPD P55212; -; . MaxQB P55212; -; . PaxDb P55212; -; . PeptideAtlas P55212; -; . PRIDE P55212; -; . DNASU 839; -; . Ensembl ENST00000265164; ENSP00000265164; ENSG00000138794. [P55212-1]; . Ensembl ENST00000352981; ENSP00000285333; ENSG00000138794. [P55212-2]; . GeneID 839; -; . KEGG hsa:839; -; . UCSC uc003hzn.2; human. [P55212-1]; . CTD 839; -; . DisGeNET 839; -; . GeneCards CASP6; -; . HGNC HGNC:1507; CASP6; . HPA CAB003775; -; . HPA HPA011337; -; . HPA HPA024303; -; . MIM 601532; gene; . neXtProt NX_P55212; -; . OpenTargets ENSG00000138794; -; . PharmGKB PA26090; -; . eggNOG KOG3573; Eukaryota; . eggNOG ENOG410ZQIE; LUCA; . GeneTree ENSGT00760000118912; -; . HOGENOM HOG000231878; -; . HOVERGEN HBG050802; -; . InParanoid P55212; -; . KO K04396; -; . OMA GNQHDVP; -; . OrthoDB EOG091G05YD; -; . PhylomeDB P55212; -; . TreeFam TF102023; -; . BRENDA 3.4.22.59; 2681; . Reactome R-HSA-111465; Apoptotic cleavage of cellular proteins; . Reactome R-HSA-264870; Caspase-mediated cleavage of cytoskeletal proteins; . Reactome R-HSA-352238; Breakdown of the nuclear lamina; . Reactome R-HSA-6803207; TP53 Regulates Transcription of Caspase Activators and Caspases; . SIGNOR P55212; -; . ChiTaRS CASP6; human; . EvolutionaryTrace P55212; -; . GeneWiki Caspase_6; -; . GenomeRNAi 839; -; . PMAP-CutDB P55212; -; . PRO PR:P55212; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000138794; -; . CleanEx HS_CASP6; -; . ExpressionAtlas P55212; baseline and differential; . Genevisible P55212; HS; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome; . GO GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central; . GO GO:0008234; F:cysteine-type peptidase activity; TAS:ProtInc; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0006915; P:apoptotic process; TAS:ProtInc; . GO GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB; . GO GO:0097194; P:execution phase of apoptosis; TAS:Reactome; . GO GO:0006508; P:proteolysis; IDA:UniProtKB; . GO GO:0042981; P:regulation of apoptotic process; TAS:Reactome; . CDD cd00032; CASc; 1; . Gene3D 3.40.50.1460; -; 1; . InterPro IPR029030; Caspase-like_dom; . InterPro IPR033139; Caspase_cys_AS; . InterPro IPR016129; Caspase_his_AS; . InterPro IPR002138; Pept_C14_p10; . InterPro IPR001309; Pept_C14_p20; . InterPro IPR015917; Pept_C14A; . PRINTS PR00376; IL1BCENZYME; . SMART SM00115; CASc; 1; . SUPFAM SSF52129; SSF52129; 1; . PROSITE PS01122; CASPASE_CYS; 1; . PROSITE PS01121; CASPASE_HIS; 1; . PROSITE PS50207; CASPASE_P10; 1; . PROSITE PS50208; CASPASE_P20; 1; .

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